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Columbus Venture Partners

‘Syngoi Technologies’: Columbus Venture Partners creates a new company in Bizkaia for the production of synthetic DNA / Una nueva empresa creada en Bizkaia para la producción de ADN sintético

Posted on November 4, 2021December 26, 2021 by info

Columbus Venture Partners has announced the creation of ‘Syngoi Technologies’, a biotechnology initiative dedicated to the production of synthetic DNA using a new proprietary enzymatic process to address the needs of advanced therapies where DNA is the fundamental starting material.

Columbus Venture Partners ha anunciado la creación de ‘Syngoi Technologies’, una iniciativa biotecnológica dedicada a la producción de ADN sintético mediante un nuevo proceso enzimático, propiedad de la empresa, que permite abordar las necesidades de las terapias avanzadas en las que el ADN es el material de partida fundamental. 

This is the case of gene therapy and mRNA-based vaccines -emerging therapeutic strategies where manufacturing is a major bottleneck. Syngoi has proprietary technology for the manufacture of its optimized synthetic DNA (or DNATM), which confers multiple advantages over traditional plasmid DNA: on the one hand, it does not require infrastructure for cell culture and production times are reduced; on the other hand, it does not contain bacterial or antibiotic-resistant genes (relevant aspects for regulatory agencies). 

It also offers important advantages over other synthetic DNAs, since it allows to optimize the therapeutic response of the gene of interest, according to the requirements of the client’s application and without any technological limitation.

‘Syngoi Technologies’ has been established in 2021 and the works of the new facilities, located in the Science and Technology Park of Bizkaia, start shortly with the aim to have the activity operational during the second quarter of 2022. In the first quarter of 2023, the plant is expected to be ready to produce in GMP (Good Manufacturing Practice) quality and to supply leading companies in the growing market of advanced therapies: gene therapy and mRNA vaccines. 

This infrastructure will involve an initial private investment of more than 10 million euros, creating dozens of direct high-level jobs. This reinforces Columbus’ commitment to the Basque Country and its position as one of the world’s leading areas in the production of advanced therapies.

“We are delighted to announce the incorporation of Syngoi. It will be Columbus’ first investment in Bizkaia and we believe it will play a key role in the synthetic DNA production market”, explains Javier García, general partner of Columbus.

About Columbus Venture Partners 

It is a venture capital investment manager with a unique focus on business opportunities in the biotechnology and life sciences sectors. The company supports the most innovative science emerging from research centers and startups, accompanying them in their development until the final commercialization of new products and treatments that offer effective solutions to unmet medical needs.

Columbus VP has nearly €235M under management in its ‘Columbus INNVIERTE Life Science’ funds and, among its investee companies is the Donostia-based Viralgen (CDMO gene therapy). Its team of professionals combines solid scientific, medical and business knowledge with extensive experience in establishing and investing in biotech companies.

+info: Columbus Venture Partners

Es el caso de la terapia génica y las vacunas basadas en mRNA –estrategias terapéuticas emergentes, donde la manufactura es un importante cuello de botella. Syngoi cuenta con tecnología propia para la manufactura de su ADN sintético optimizado (o DNATM), que confiere múltiples ventajas sobre el ADN plasmídicotradicional: Por un lado, no requiere infraestructura para cultivo celular y se reducen los tiempos de producción; por otra parte, no contiene genes de bacteria ni resistentes a antibióticos (aspectos relevantes para las agencias reguladoras). 

Ofrece además importantes ventajas sobre otros ADN sintéticos, ya que permite optimizar la respuesta terapéutica del gen de interés, según los requerimientos de la aplicación del cliente y sin ningún tipo de limitación tecnológica.

‘Syngoi Technologies’ se ha creado en 2021 y las obras de las nuevas instalaciones, ubicadas en el Parque Científico y Tecnológico de Bizkaia, comienzan en breve con el fin de que la actividad se encuentre operativa durante el segundo trimestre de 2022. En el primer trimestre de 2023 la planta se prevé que esté preparada para producir en calidad GMP (Normas de Correcta Fabricación) y sea proveedora de las empresas líderes en el creciente mercado de terapias avanzadas: terapia génica y vacunas de mRNA. 

Esta infraestructura supondrá una inversión privada inicial superior a los 10 millones de euros, creando para ello decenas de puestos de trabajo directos de alto nivel. Se refuerza así la apuesta de Columbus por Euskadi y su posicionamiento como una de las áreas de referencia en producción de terapias avanzadas del mundo.

“Estamos encantados de anunciar la constitución de Syngoi. Será la primera inversión de Columbus en Bizkaia y pensamos que tendrá un papel clave en el mercado de producción de ADN sintético”, explica Javier García, general partner de Columbus.

Acerca de Columbus Venture Partners 

Se trata de una gestora de inversiones de capital riesgo con un enfoque único en oportunidades de negocio del sector biotecnológico y Ciencias de la Vida. La Compañía apoya la ciencia más innovadora que surge en centros de investigación y startups, acompañando en su desarrollo hasta la comercialización final de nuevos productos y tratamientos que ofrecen soluciones efectivas a necesidades médicas no cubiertas. 

Columbus VP tiene bajo gestión cerca de €235M en sus fondos ‘Columbus INNVIERTE Life Science’ y, entre sus empresas participadas se encuentra la donostiarra Viralgen (CDMO terapia génica). Su equipo de profesionales combina un sólido conocimiento científico, médico y empresarial con una amplia experiencia en el establecimiento e inversión en empresas biotecnológicas.

+info: Columbus Venture Partners

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